ParkinsonCanadaV1, Main, Exploration, bibRecord, 002104

Dysfunction of the Default Mode Network in Parkinson Disease: A Functional Magnetic Resonance Imaging Study

Identifieur interne : 002104 ( Main/Exploration ); précédent : 002103; suivant : 002105

Dysfunction of the Default Mode Network in Parkinson Disease: A Functional Magnetic Resonance Imaging Study

Auteurs : Thilo Van Eimeren [Canada] ; Oury Monchi [Canada] ; Benedicte Ballanger [Canada] ; Antonio P. Strafella [Canada]

Source :

Archives of neurology : (Chicago) [ 0003-9942 ] ; 2009.

RBID : Pascal:09-0330747

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Trouble fonctionnel, Imagerie fonctionnelle, Imagerie RMN.

English descriptors

KwdEn :
- Aged, Brain Mapping, Cerebral Cortex (blood supply), Cerebral Cortex (physiopathology), Dysfunction, Female, Functional imaging, Humans, Image Processing, Computer-Assisted (methods), Magnetic Resonance Imaging (methods), Male, Middle Aged, Nerve Net (blood supply), Nerve Net (pathology), Nervous system diseases, Neural Pathways (blood supply), Neural Pathways (pathology), Neural Pathways (physiopathology), Neuropsychological Tests, Nuclear magnetic resonance imaging, Oxygen (blood), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson disease, Problem Solving (physiology), Statistics as Topic.
MESH :
- chemical , blood : Oxygen.
- blood supply : Cerebral Cortex, Nerve Net, Neural Pathways.
- methods : Image Processing, Computer-Assisted, Magnetic Resonance Imaging.
- pathology : Nerve Net, Neural Pathways, Parkinson Disease.
- physiology : Problem Solving.
- physiopathology : Cerebral Cortex, Neural Pathways, Parkinson Disease.
- Aged, Brain Mapping, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Statistics as Topic.

Abstract

Objective: To examine the integrity of the default mode network in patients with Parkinson disease (PD). Previous functional neuroimaging experiments have studied executive deficits in patients with PD with regard to task-related brain activation. However, recent studies suggest that executive performance also relies on the integrity of the default mode network (ie, medial prefrontal cortex, posterior cingulate cortex, precuneus, and lateral parietal and medial temporal cortices), characterized by a deactivation of these cortical areas during the performance of executive tasks. Design: We used functional magnetic resonance imaging to investigate cortical deactivations during a card-sorting task (retrieval and manipulation of short-term memory contents) compared with a simple sensory-motor matching task. In addition, a functional connectivity analysis was performed. Setting: Tertiary outpatient clinic. Participants: Seven patients with mild to moderate PD (not taking medication) and 7 healthy controls. Main Outcome Measure: Cortical deactivations. Results: Both groups showed comparable deactivation of the medial prefrontal cortex but different deactivation in the posterior cingulate cortex and the precuneus. Compared with controls, patients with PD not only showed less deactivation of the posterior cingulate cortex and the precuneus, they even demonstrated a reversed pattern of activation and deactivation. Connectivity analysis yielded that in contrast to healthy individuals, medial prefrontal cortex and the rostral ventromedial caudate nucleus were functionally disconnected in PD. Conclusions: We describe specific malfunctioning of the default mode network during an executive task in PD. This finding is plausibly linked to dopamine depletion and may critically contribute to the understanding of executive deficits in PD.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972248

Affiliations:

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<front><div type="abstract" xml:lang="en">Objective: To examine the integrity of the default mode network in patients with Parkinson disease (PD). Previous functional neuroimaging experiments have studied executive deficits in patients with PD with regard to task-related brain activation. However, recent studies suggest that executive performance also relies on the integrity of the default mode network (ie, medial prefrontal cortex, posterior cingulate cortex, precuneus, and lateral parietal and medial temporal cortices), characterized by a deactivation of these cortical areas during the performance of executive tasks. Design: We used functional magnetic resonance imaging to investigate cortical deactivations during a card-sorting task (retrieval and manipulation of short-term memory contents) compared with a simple sensory-motor matching task. In addition, a functional connectivity analysis was performed. Setting: Tertiary outpatient clinic. Participants: Seven patients with mild to moderate PD (not taking medication) and 7 healthy controls. Main Outcome Measure: Cortical deactivations. Results: Both groups showed comparable deactivation of the medial prefrontal cortex but different deactivation in the posterior cingulate cortex and the precuneus. Compared with controls, patients with PD not only showed less deactivation of the posterior cingulate cortex and the precuneus, they even demonstrated a reversed pattern of activation and deactivation. Connectivity analysis yielded that in contrast to healthy individuals, medial prefrontal cortex and the rostral ventromedial caudate nucleus were functionally disconnected in PD. Conclusions: We describe specific malfunctioning of the default mode network during an executive task in PD. This finding is plausibly linked to dopamine depletion and may critically contribute to the understanding of executive deficits in PD.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Dysfunction of the Default Mode Network in Parkinson Disease: A Functional Magnetic Resonance Imaging Study

Dysfunction of the Default Mode Network in Parkinson Disease: A Functional Magnetic Resonance Imaging Study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.